Abbas Ali Taherian; Mehdi Zahedi Khorasani; Zahra Mollashahi; Abbas Ali Vafaei
Volume 15, Issue 2 , July and August 2008, , Pages 65-72
Abstract
Background and Purpose: Previous studies suggest that the leaf of Trigonella foenum (TF) has analgesic anti-inflammatory and probably modulatory effects on sleep and anxiety reactions. The present study is intended to determine the effects of hydro - alcoholic extract of TF on anxiety and sleeping time ...
Read More
Background and Purpose: Previous studies suggest that the leaf of Trigonella foenum (TF) has analgesic anti-inflammatory and probably modulatory effects on sleep and anxiety reactions. The present study is intended to determine the effects of hydro - alcoholic extract of TF on anxiety and sleeping time in mice. Methods and Materials: In this experimental study 140 male albino mice (25-30 gr) were used in 14 groups (n=10 in each group). Elevated plus maze (EPM) was used for the assessment of anxiety and experimental groups received hydro-alcoholic extracts of TF (50 100 200 400 and 80 mg/kg) as IP injection; sham group received saline (10 mg/kg IP injection) 30 minutes prior to evaluation; the control group did not receive any injection. 25 minutes after injection animals were put in a black box for 5 minutes in order to increase their activity; then they were transferred to the EPM for anxiety evaluation by two factors: the time spent and frequency of entrance to the open arms of the EPM. In order to assess sleeping time the Angel method (records of sleeping duration by physiograph) was used. 30 minutes before sleep assessment TF extract and saline were used for experimental and sham groups; the control group received nothing as what we did in anxiety evaluation. Finally ANOVA and Tukey tests were used for data analysis. Results: The findings indicated that the hydro-alcoholic extract of TF in doses of 100 and 200 mg/kg significantly increased the time spent and frequency of entrance to the open arms of EPM (p
AA VAFAEI; S HAJ RAHIM KHAN; M ZAHEDI KHORASANI; M JARAHI; ABAS ALI TAHERIAN; H MILADI GORJI; H SADEGHI
Volume 15, Issue 1 , March and April 2008, , Pages 7-13
Abstract
Background and Purpose: Cuminum Cyminm (CC) is one of the plants whose aqueous extract is used in traditional medicine as anti-convulsive anti-epileptic and as a treatment for some visceral pains. However no substantial reports can be found of its effects on the peripheral pain in lab animals. Therefore ...
Read More
Background and Purpose: Cuminum Cyminm (CC) is one of the plants whose aqueous extract is used in traditional medicine as anti-convulsive anti-epileptic and as a treatment for some visceral pains. However no substantial reports can be found of its effects on the peripheral pain in lab animals. Therefore this study was condcated to determine the effects of the IP injection of the aqueous extract of CC on the acute peripheral pain in Hot Plate (HP) and Tail Flick (TF) tests in mice.
Methods and Materials: This experimental study was conducted on 56 male Albino mice (8 groups each with 7 mice) weighing 25-30 gr. 200 and 500 mg/kg of the aqueous extract of CC or saline of the volume were injected intraperitoeally 30 minutes prior to the tests. Pain measrment criteria in the TF test was the response time to the pain by raising the tail and in the HP test the time to begin to lick the front legs or raising the rear feet.
Results: The IP injection of the CC aqueous extract with the doses of 200 and 500 mg/kg significantly increased the response time to the pain in HP and TF tests (P